Disease Areas

At BirchBioMed, we are dedicated to tackling some of the most challenging and debilitating conditions related to fibrosis and autoimmune disorders. We are currently focused on the development of our two primary products. FS2 ((kynurenic acid, or KynA) is being developed to address hypertrophic and keloid scars, and idiopathic pulmonary fibrosis, while AC1 AI-001 is our novel, proprietary combination of KynA with antigen-presenting cells (APCs) to treat certain autoimmune disorders, beginning with type 1 diabetes, and alopecia areata.

Topical Scarring & Burns

Scars, or fibrosis, often result from aberrant tissue repair processes. Fibrosis occurs when normal tissue repair pathways become dysregulated, causing excessive deposits of collagen and fibronectin in wounds and affected organs that ultimately impair their physiological function. More than 100 million patients develop scars each year as a result of 55 million elective procedures and 25 million surgeries following trauma in the developed world alone. Scars also form following any insult to the deep dermis, including burns, lacerations, abrasions, piercings, and vaccinations.

Organ Fibrosis

Organ fibrosis is a pathological process characterized by excessive accumulation of extracellular matrix (ECM) proteins, leading to scarring and tissue hardening. This condition can affect the liver, lungs, kidneys, and heart, and often results from chronic inflammation or injury. In the developed world, organ fibrosis is a significant health concern, contributing to nearly 45% of all deaths due to its association with chronic diseases such as liver cirrhosis, idiopathic pulmonary fibrosis (IPF), and chronic kidney disease.

Autoimmune Disorders

Autoimmune disorders occur when the immune system, which typically protects the body from harmful invaders, attacks its own healthy cells and tissues. A combination of genetic predisposition and environmental factors often triggers this misdirected response. Autoimmune diseases can target various organs and systems, leading to a wide range of conditions such as type 1 diabetes, alopecia areata, rheumatoid arthritis, and lupus.

Wrinkles & Rhytids

Wrinkles and rhytids, also known as facial lines, are natural skin changes that occur as part of the aging process, reflecting decreased skin elasticity and volume. These changes are mainly due to the breakdown of collagen and elastin fibers, dehydration, and the cumulative effects of sun exposure and environmental stressors.